- Robotstudio target external axis how to#
- Robotstudio target external axis manual#
- Robotstudio target external axis Pc#
Among the intrinsic and extrinsic factors behind the radioresistance of cancer cells, gene networks responsible for the production of antioxidants have drawn considerable attention in recent years 6, 13. It has been widely accepted that the so-called chemo-radiotherapy, a combination of radiation therapy with chemotherapeutic agents, which appropriately controls these complexities, is a rational strategy to overcome radioresistance 5, 10. Accumulating evidence has demonstrated that several factors, such as the cell cycle status, DNA damage repair activity, oxygen-availability, and pH, intricately influence one another and eventually lead to the radioresistant properties of cancer cells 6, 7, 8, 9, 10, 11, 12. However, patients often suffer from local tumor recurrence after radiation therapy due to the presence of radioresistant cancer cells in malignant solid tumors 4, 5, 6. As a result radiation therapy has become increasingly important in cancer therapy and is now applied globally for a growing number of cancer patients 2, 3. Significant technological improvements in the field of radiation therapy, such as three-dimensional conformal radiation therapy (3D-CRT), intensity-modulated radiation therapy (IMRT) 1, and image-guided radiation therapy (IGRT), have facilitated both dose escalations to target volumes and dose-sparing to normal tissues 2. These results collectively suggest that cancer cells acquire antioxidant and radioresistant phenotypes through UCHL1-HIF-1-mediated metabolic reprogramming including the activation of PPP and provide a rational basis for targeting this gene network for radiosensitization. The pharmacological inhibition of PPP canceled the UCHL1-mediated radioresistance. The UCHL1-mediated reprogramming elevated intracellular GSH levels, and consequently induced a radioresistant phenotype in a HIF-1-dependent manner. UCHL1 overexpression induced the reprogramming of carbohydrate metabolism and increased NADPH levels in a pentose phosphate pathway (PPP)-dependent manner. A luciferase assay to monitor HIF-1 activity demonstrated that the overexpression of UCHL1, but not its deubiquitination activity-deficient mutant (UCHL1 C90S), upregulated HIF-1 activity by stabilizing the regulatory subunit of HIF-1 (HIF-1α) in a murine breast cancer cell line, EMT6. Here, we show that Ubiquitin C-terminal hydrolase-L1 (UCHL1), which we previously identified as a novel HIF-1 activator, increased the radioresistance of cancer cells by producing an antioxidant, reduced glutathione (GSH), through HIF-1-mediated metabolic reprogramming. Although this reprogramming has been associated with the antioxidant and radioresistant properties of cancer cells, gene networks triggering the HIF-1-mediated reprogramming and molecular mechanisms linking the reprogramming with radioresistance remain to be determined.
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in this video i have explained the basic concept of smart simulation made for the robotstudio challenge competition.Hypoxia-inducible factor 1 (HIF-1) has been recognized as an important mediator of the reprogramming of carbohydrate metabolic pathways from oxidative phosphorylation to accelerated glycolysis.
Robotstudio target external axis how to#
we have this video is part 1 on how to create a smart component in robot studio. in this project we used 2 abb irb52 paint robots to paint these tee valves, de conveyor is made with a start stop system. our robotics class is mainly geared towards autonomous and agile robotics. i've been tasked with creating an introduction to robotics course at my community college. hello all, i have a couple of questions for you guys if you dont mind. Robotstudio help introduction to robotics.
Robotstudio target external axis manual#
Abb robotics operating manual robotstudio 10.
Robotstudio target external axis Pc#
abb's simulation and offline programming software, robotstudio, allows robot programming to be done on a pc in the office without shutting down production, this allows you to perform tasks such as training, programming, and optimization without disturbing the production. Offline programming is the best way to maximize return on investment for robot systems. swept volume this tutorial shows how to generate an approximate total volume of the robot and tool movement along a path as well as the approximate stop. In this tutorial you will learn how to visualize the robot position after a category 0 and 1 stop and to measure the distance between the robot at its stop position and the environment.